Clinical effects of fractional carbon dioxide laser combined with minimally invasive scar release in the treatment of post-acne atrophic scars / 中华烧伤杂志

Objective: To explore the clinical effects of fractional carbon dioxide laser combined with minimally invasive scar release in the treatment of post-acne atrophic scars. Methods: A retrospectively observational study was conducted. From January to June 2021, 60 patients with grade 3 and 4 post-acne atrophic scars who met the inclusion criteria were admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine. According to the adopted treatment methods, 30 patients treated with fractional carbon dioxide laser combined with minimally invasive scar release were included in combined treatment group (19 males and 11 females, aged (26±4) years), and 30 patients treated with fractional carbon dioxide laser alone were included in laser alone group (18 males and 12 females, aged (25±6) years). All the patients received the treatment once every two months, totally 3 times. Before the first treatment and 2 months after the last treatment, the scars were assessed by échelle d'évaluation clinique des cicatrices d'acné (ECCA). In 2 months after the last treatment, the curative effect was evaluated and the total effective rate was calculated according to the ECCA score. The adverse reactions of patients during the treatment were recorded. Data were statistically analyzed with independent sample t test, Wilcoxon rank-sum test, Mann-Whitney U test, chi-square test, and Fisher's exact probability test. Results: Before the first treatment, the ECCA scores of patients in the two groups were similar (P>0.05). In 2 months after the last treatment, the ECCA scores of patients in combined treatment group were significantly lower than those of laser alone group (Z=-2.89, P<0.05). The ECCA scores of patients in combined treatment group and laser alone group in 2 months after the last treatment were both significantly lower than those before the first treatment (with Z values of -4.81 and -4.79, respectively, P<0.05). In 2 months after the last treatment, the treatment in laser alone group cured the scars in 2 patients, and were markedly effective in 13 patients, effective in 7 patients, and ineffective in 8 patients; the treatment in combined treatment group cured the scars in 4 patients, and were markedly effective in 22 patients, effective in 3 patients, and ineffective in one patients. The total effective rate of scar treatment in combined treatment group (96.67%, 29/30) was significantly higher than 73.33% (22/30) in laser alone group (P<0.05). During treatment, in combined treatment group, 3 patients had pain, one patient had redness and swelling, and one patient had pigmentation. In laser alone group, one patient had pain, and 2 patients had pigmentation. No infection occurred in the wounds of all the patients in the two groups. Conclusions: Compared with fractional carbon dioxide laser alone, fractional carbon dioxide laser combined with minimally invasive scar release for post-acne atrophic scars can result in a higher total effective rate, with simple operation and good effect, so it is worthy of clinical application.

Acné en la adolescencia: como reconocerlo y abordarlo / Acne in adolescents: how to recognize it and treat it / Acne na adolescencia: como reconhecer-lo e tratá-lo

El acné una de las enfermedades dermatológicas crónicas más frecuentes, siendo la adolescencia donde se observa su mayor incidencia y prevalencia. Constituye un motivo de consulta frecuente y a pesar de que su abordaje inicial es de resorte del pediatra, dependiendo de la evolución y los tipos de acné requieren la derivación y tratamiento con dermatólogo. Es una enfermedad cutánea, de carácter inflamatorio y que involucra la unidad pilosebácea. Su etiología es multifactorial y el diagnóstico es clínico al constatar las lesiones típicas. Teniendo en cuenta la importancia de la imagen corporal en esta etapa de la vida y el impacto de esta en la calidad de vida de los adolescentes, es imprescindible el reconocimiento precoz y tratamiento inicial por parte del pediatra. Existen posibilidades terapéuticas cada vez más novedosas, exigiendo a los profesionales de salud estar actualizados. Esta revisión pretende mostrar una puesta al día de la temática y ofrecer información actualizada sobre los tratamientos disponibles a nivel local.

Acne is one of the most common chronic dermatological diseases and it is primarily observed in adolescents. It is one of the causes of frequent consultation, and despite the fact that Its initial detection and approach is that of the pediatrician, depending on the evolution and the types of acne, referral and treatment by a dermatologist will be required. It is a skin disease, inflammatory in nature and involving the pilosebaceous unit. It has a multifactorial etiology and it requires clinical diagnosis when typical lesions are found. Considering importance of adolescents' image at this stage and the impact on their quality of life, early detection and treatment by the pediatrician are essential. There are increasing new therapeutic possibilities, which require health professionals to be updated. This review aims at showing an update of the subject and at providing updated information regarding the available treatments locally.

A acne é uma das doenças dermatológicas crônicas mais comuns, sendo a adolescência onde observase sua maior incidência e prevalência. Constitui motivo de consulta frequente e apesar de sua abordagem inicial é a do pediatra, dependendo da evolução e dos tipos de acne que necessitam de tratamento e encaminhamento feito por um dermatologista. É uma doença cutânea, de natureza inflamatória e que envolve a unidade pilossebácea. Sua etiologia é multifatorial e o diagnóstico é clínico quando são encontradas lesões típicas. Tendo em conta a importância da imagem corporal nesta fase da vida e o impacto dela na qualidade de vida dos adolescentes, o reconhecimento inicial pelo pediatra e o tratamento precoces são essenciais. Existem cada vez mais novas possibilidades terapêuticas, exigindo que os profissionais de saúde estejam atualizados. Este papertem como objetivo mostrar uma atualização do assunto e fornecer informação atualizada sobre os tratamentos disponíveis a nível local.

Body dysmorphia and selfie behavior of Filipino patients with and without mild acne vulgaris: A descriptive cross-sectional study

Background@#Acne vulgaris (AV) is a chronic inflammatory skin condition that is non-life-threatening but may cause significant psychological morbidity regardless of severity. An extreme case of this is depicted in body dysmorphic disorder (BDD), which is often an undiagnosed condition presenting with excessive preoccupation of perceived flaws not observable by others. With the increasing popularity of social media throughout the years, there has been budding researches exploring its psychological implications, particularly on “selfies” and its possible association with self-image and body dysmorphia.@*Objectives@#To compare body dysmorphic symptoms and selfie behavior between patients with mild AV versus those without AV. Methods This is a single-center, cross-sectional study among patients with mild AV and those without AV seen through a teledermatology platform of a tertiary hospital from April to June 2022. @*Results@#A total of 207 patients were included in this study – 107 patients with mild AV and 100 patients without AV. A significantly higher proportion of BDD symptoms was seen in patients with mild AV using either Body Dysmorphic Disorder Questionnaire-Dermatology Version (BDDQ-DV) (31%) and Dysmorphic Concern Questionnaire (DCQ) (14%). No significant difference was noted in terms of selfie behavior between the groups. @*Conclusions@#BDD symptoms were significantly more prevalent in patients who have mild AV despite having lesions that are negligible and clinically not apparent. This highlights the importance of dermatologists’ knowledge that BDD may cause distress and impairment and should be taken into consideration in terms of management. Interestingly, selfie behavior of patients with mild AV and without AV had no significant difference.

Relationship of whole blood zinc levels to acne severity among Filipinos 18-25 years old: A cross-sectional comparative study in a tertiary government hospital

@#<p style="text-align: justify;"><strong>INTRODUCTION:</strong> Acne Vulgaris is one of the most common dermatologic diagnoses in the world. It can persist for years, result in permanent scarring, and have serious adverse effects on psychosocial development.</p><p style="text-align: justify;"><strong>OBJECTIVES:</strong> This study aims to determine the relationship between whole blood zinc levels and severity of acne.</p><p style="text-align: justify;"><strong>METHODS:</strong> This is a cross-sectional comparative study. Whole blood zinc levels of 30 patients with acne vulgaris divided into mild (n=10), moderate (n=10), and severe (n=10), and 10 healthy patients were measured. Acne severity was evaluated using the Global Acne Grading System (GAGS).</p><p style="text-align: justify;"><strong>RESULTS:</strong> A total of 40 patients participated in this study. The mean whole blood zinc level in acne patients and non-acne patients were 5.03 ± 1.92 mcg/mL and 7.39 ± 0.79 mcg/mL, respectively. The mean zinc level of the controls was significantly higher compared to that of the acne patients (p=0.0006). Furthermore, mean whole blood zinc level of the patients with severe acne was significantly lower compared to that of the controls, mild acne and moderate acne (p<0.001). Adjusting for age and sex, there is a significant association between severity of acne vulgaris and blood zinc levels (p<0.0001). Specifically, the mean blood zinc level of the patients with moderate and severe acne were significantly lower compared to that of the control group (p=0.019 and p<0.001, respectively).</p><p style="text-align: justify;"><strong>CONCLUSION:</strong> Whole blood zinc levels were inversely correlated with acne vulgaris severity in the Filipino population. Further studies are recommended to determine the role of zinc in the pathogenesis of acne and the effects of oral zinc supplementation on acne patients.</p>

Research advances on mesenchymal stem cells and their derivatives in the treatment of acne scars / 中华烧伤杂志

Acne is a common chronic inflammatory disease of the skin that often occurs on the face, and acne scars are often secondary to the healing process of acne, which often leads to impaired appearance and psychological disorders of patients. The current treatment for acne scars is extremely difficult. With the development of regenerative medicine, stem cell transplantation has become a new treatment for acne scars. In recent years, it has been reported that stem cells and their derivatives can effectively antagonize the formation of acne scars. Therefore, this paper briefly reviews the basic and clinical researches on the treatment of acne scars with various mesenchymal stem cells and their derivatives, aiming to provide theoretical basis and reference for the stem cell therapy of acne scars.

Clinical observation on different frequency of auricular bloodletting combined with auricular point sticking for acne vulgaris / 中国针灸

OBJECTIVE@#To observe the clinical efficacy of different treatment frequency of auricular bloodletting combined with auricular point sticking for acne vulgaris.@*METHODS@#A total of 90 patients with acne vulgaris were randomized into a treatment group 1 (30 cases, 2 cases dropped off), a treatment group 2 (30 cases, 4 cases dropped off) and a treatment group 3 (30 cases, 5 cases dropped off). Combination therapy of auricular bloodletting and auricular point sticking at Fei (CO14), Shenmen (TF4), Neifenmi (CO18) and Shenshangxian (TG2p) were given once a week, twice a week and 3 times a week in the treatment group 1, the treatment group 2 and the treatment group 3 respectively, 4 weeks were as one course and totally 3 courses were required in the 3 groups. Before treatment and after 1, 2, 3 courses of treatment, the scores of global acne grading system (GAGS), skin lesion and quality of life-acne (QoL-Acne) were observed, the clinical efficacy was evaluated after 3 courses of treatment and the recurrence rate was evaluated in follow-up of 1 month after treatment in the 3 groups.@*RESULTS@#Compared before treatment, the scores of GAGS and skin lesion were decreased at each time point in the 3 groups (P<0.05), the QoL-Acne scores were increased after 1 course of treatment in the treatment group 3 and after 2, 3 courses of treatment in the 3 groups (P<0.05). There were no statistical differences in scores of GAGS, skin lesion and QoL-Acne among the 3 groups (P>0.05). There were no statistical differences in effective rate and recurrence rate among the 3 groups (P>0.05).@*CONCLUSION@#Different frequency of auricular bloodletting combined with auricular point sticking have similar efficacy in treating acne vulgaris, all can improve the skin lesion and quality of life in patients with acne vulgaris, and have a cumulative effect and good long-term curative effect.

Preparation of tanshinone Ⅱ_A-glycyrrhetinic acid solid lipid nanoparticles and its inhibitory effect on acne / 中国中药杂志

The optimal prescription of tanshinone Ⅱ_A(TSN)-glycyrrhetinic acid(GA) solid lipid nanoparticles(GT-SLNs) was explored and evaluated in vivo and in vitro, and its effect on acne after oral administration was investigated. The preparation processing and prescription were optimized and verified by single factor and response surface methodology. The in vitro release of GA and TSN in GT-SLNs was determined by ultra-performance liquid chromatography(UPLC). The effect of GT-SLNs on acne was investigated by the levels of sex hormones in mice, ear swelling model, and tissue changes in sebaceous glands, and the pharmacokinetics was evaluated. The 24-hour cumulative release rates of GA and TSN in SLNs were 65.87%±5.63% and 36.13%±2.31% respectively. After oral administration of GT-SLNs and the mixture of GA and TSN(GT-Mix), the AUC_(0-t) and AUC_(0-∞) of TSN in GT-SLNs were 1.98 times and 4.77 times those in the GT-Mix group, respectively, and the peak concentration of TSN in the GT-SLNs group was 17.2 times that in the GT-Mix group. After intragastric administration of GT-SLNs, the serum levels of testosterone(T) and the ratio of testosterone to estradiol(T/E2) in the GT-SLNs group significantly declined, and the sebaceous glands of mice were atrophied to a certain extent. The results demonstrated that obtained GT-SLNs with good encapsulation efficiency and uniform particle size could promote the release of GA and TSN. GT-SLNs displayed therapeutic efficacy on acne manifested by androgen increase, abnormal sebaceous gland secretion, and inflammatory damage.

Clinical Observation of Recombinant Bovine Basic Fibroblast Growth Factor as an Adjuvant Therapy for Patients with Atrophic Acne Scar / 中国医学科学院学报

Objective To study the influence of recombinant bovine basic fibroblast growth factor as an adjuvant therapy on scar alleviation and inflammatory cytokines in patients with atrophic acne scar. Methods The random number table was employed to randomly assign 120 patients with atrophic acne scar into a test group and a control group.Both groups of patients were treated with CO2 lattice laser.After the operation,the control group was routinely smeared with erythromycin ointment and the test group was coated with recombinant bovine basic fibroblast growth factor gel.The clinical efficacy,clinical indicators,scar alleviation,and inflammatory cytokine levels before and after treatment were compared,and adverse reactions were counted. Results The test group had higher total effective rate(P=0.040) and lower total incidence of adverse reactions(P=0.028) than the control group.Compared with the control group,the test group showcased short erythema duration after treatment(P=0.025),early scab forming(P=0.002),and early edema regression(P<0.001).After treatment,the proportion of grade 1 scars graded by Goodman and Baron's acne scar grading system in the test group and control group increased(P=0.001,P=0.027),and the proportion of grade 4 scars decreased(P<0.001,P=0.034).Moreover,the proportion of grade 1 scars in the test group was higher than that in the control group(P=0.031) after treatment,and the proportion of grade 4 scars presented an opposite trend(P=0.031).After treatment,the levels of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in both groups declined(all P<0.001),and the test group had lower TNF-α and IL-1β levels than the control group(all P<0.001). Conclusion The recombinant bovine basic fibroblast growth factor gel as an adjuvant therapy of CO2 lattice laser can effectively alleviate the atrophic acne scar,relieve local inflammatory reaction,and has good curative effect and less adverse reactions.

Clinical efficacy of 585 nm Q-switched laser treatment on inflammatory lesion and postinflammatory erythema of acne vulgaris / 北京大学学报(医学版)

OBJECTIVE@#To evaluate the efficacy and safety of 585 nm Q-switched laser in the treatment of acne inflammatory lesions and postinflammatory erythema.@*METHODS@#A total of 25 patients with moderate facial acne, symmetrical distribution of inflammatory lesions and postinflammatory erythema on both sides of the face, were enrolled. Among the 25 patients, 22 patients completed all the treatment and evaluation, and 3 patients were lost to follow-up. 585 nm Q-switched laser was used on a randomly selected side of the face for three times of treatment at a 2 week interval. The evaluations were made before each treatment, 2 and 4 weeks after the last treatment, therefore the evaluation time points were before the treatment, weeks 2, 4, 6, and 8, respectively, for a total of 5 times. Acne severity was assessed using the investigator' s global assessment (IGA) score, and erythema severity was assessed using the investigator' s subjective erythema score and narrow-spectrum reflectance spectrophotometer at each follow-up.@*RESULTS@#After 3 times of treatment, there was statistically significant difference between the IGA score in week 8 and before treatment on both sides(Z=2.64, P < 0.01; Z=2.67, P < 0.01). There was no significant difference in IGA score between the treatment side and the control side before treatment and in week 8 (P=0.59, P=0.26). There was statistically significant difference between the investiga-tor' s subjective erythema score in week 8 and before treatment on the treatment side(Z=4.24, P < 0.01), while no significant difference was showed on the control side(Z=1.73, P=0.08). In week 8, the investigator's subjective erythema score of the treatment side was lower than that of the control side (Z=3.61, P < 0.01). The erythema index of the treatment side was significantly decreased at 5 time points (P < 0.01), and the index decreased significantly in week 8 compared with the index before treatment (P < 0.01), while the erythema index of the control side was not significantly different at 5 time points. The treatment related adverse events included erythema and edema after treatment and pain during treatment, the severity was mild to moderate, which resolved spontaneously within 1 to 3 days. Nine patients were very satisfied with the treatment, 7 patients were satisfied, and 6 patients considered average.@*CONCLUSION@#585 nm Q-switched laser has some effect in the treatment of postinflammatory erythema, and it ensures good tolerance and safety. There was no statistically significant difference between the treatment side and the control side on the improvement of acne inflammatory lesions.

Revisión del papel de las plantas medicinales en el tratamiento del acné / A review on the role of medicinal plants in treatment of acne

Antecedentes: el acné vulgar es un trastorno cutáneo muy común que puede presentarse con lesiones inflamatorias y no inflamatorias principalmente en la cara, pero también puede ocurrir en la parte superior de los brazos, el tronco y la espalda. El tratamiento del acné es de gran importancia y el acné vulgar y, por lo tanto, la bacteria que causa el acné, P. acnes, se han estudiado intensamente y se han propuesto varias soluciones. Sin embargo, poca investigación se ha centrado en el uso de plantas medicinales para el tratamiento de esta enfermedad de la piel. Sin embargo, hay una serie de plantas medicinales que se utilizan tradicionalmente para tratar el acné, y esto proporciona el ímpetu para que los científicos exploren sus propiedades medicinales. Objetivo: Este trabajo tuvo como objetivo revisar los enfoques de tratamiento a base de plantas medicinales para el acné. Metodología: Se realizaron búsquedas en las bases de datos científicas en línea autorizadas, incluidas Pubmed, MEDLINE, Link of Springer, Online Library of Wiley, Science Direct of Elsevier, Cambridge Core y Cochrane, y se recopilaron, combinaron y analizaron los datos útiles asociados con el objetivo del presente estudio. luego categorizado en términos de plantas medicinales, acné, acné vulgar, hierbas. Conclusión: Actualmente existe un fuerte enfoque en las plantas medicinales a nivel de investigación y, por lo tanto, existe una fuerte motivación para el uso de estos ingredientes en productos para el cuidado cosmético que deben probarse como seguros y efectivos con la ayuda de la investigación clínica

Background: Acne Vulgaris is a very common skin disorder which can present with inflammatory and non-inflammatory lesions chiefly on the face but can also occur on the upper arms, trunk, and back. Treatment of acne is of a high importance and acne vulgaris and thus the acne-causing bacterium, P. acnes, have been intensively studied and several solutions have been proposed. Nevertheless, little research has focused on the use of medicinal plants for the treatment of this skin disease. However, there are a number of medicinal plants used traditionally to treat acne, and this provides the impetus for scientists to explore their medicinal properties. Objective: This work aimed to review medicinal plants-based treatment approaches for acne. Methodology: The authoritative online scientific databases including Pubmed, MEDLINE, Link of Springer, Online Library of Wiley, Science Direct of Elsevier, Cambridge Core, and Cochrane were searched and the useful data associated with the objective of present study were gathered, combined, and then categorized in terms of medicinal plants, acne, Acne Vulgaris, herbs. Conclusion: There is currently a strong focus on medicinal plants at a research level and therefore strong motivation exists for the use of these ingredients in cosmetic care products that need to be proven safe and effective with the aid of clinical research.

Avaliação do tratamento de alterações estéticas faciais com uso de um protocolo operacional desenvolvido para a aplicação de plasma rico em plaquetas / Evaluation of the treatment of changes aesthetic facial with the use of an operational protocol developed for the application of platelet rich plasm

Introdução: o plasma rico em plaquetas é definido como um concentrado de plaquetas autólogas, obtido por centrifugação de sangue total. Trata-se de uma técnica inovadora, simples e de baixo custo, que apresenta muitos benefícios, podendo ser aplicada em diferentes áreas da saúde. Objetivo: a presente pesquisa buscou desenvolver um protocolo operacional padrão para obtenção e aplicação do plasma sanguíneo rico em plaquetas para o tratamento de alterações estéticas faciais. Metodologia: o estudo tratou de uma pesquisa de campo experimental, de caráter qualitativo e quantitativo. Um processo seletivo foi realizado para recrutar pacientes voluntários para o estudo, que foram selecionados de acordo com os critérios de inclusão e exclusão. Através de testes foi possível chegar ao tempo de centrifugação e velocidade ideais para a produção do plasma rico em plaquetas e testá-lo no tratamento de alterações estéticas faciais. Resultados e discussão: as principais mudanças que foram notadas pelos pacientes durante e após o tratamento foram a redução das cicatrizes de acne e aumento da hidratação e viscosidade da pele. A melhora das alterações estéticas tratadas foi notada por 100% dos pacientes, não havendo piora em nenhum paciente. Conclusão: com base nos testes e resultados obtidos, foi possível padronizar um protocolo operacional padrão ideal para a obtenção e aplicação do plasma rico em plaquetas, comprovando sua eficácia no tratamento de alterações estéticas faciais como rugas, flacidez, linhas de expressões acentuadas, acne, cicatrizes de acne, além de ter-se observado uma melhora significativa na hidratação da pele e redução de poros dilatados.

Introduction: platelet-rich plasma is defined as a concentrate of autologous platelets, obtained by centrifuging whole blood. It is an innovative, simple and low-cost technique that has many benefits, and can be applied in different areas of health. Objective: the present research sought to develop a standard operating protocol for obtaining and applying platelet-rich blood plasma for the treatment of facial aesthetic changes. Metodology: the study was a qualitative and quantitative field research. A selection process was carried out to recruit volunteer patients for the study, who were selected according to the inclusion and exclusion criteria. Through tests it was possible to reach the ideal centrifugation time and speed for the production of platelet-rich plasma and to test it in the treatment of facial aesthetic changes. Results and discussion: the main changes that were noted by patients during and after treatment were the reduction of acne scars and increased hydration and skin viscosity. The improvement of the aesthetic changes treated was noticed by 100% of the patients, with no worsening in any patient. Conclusion: based on the tests and results obtained, it was possible to standardize an ideal standard operating protocol for obtaining and applying platelet-rich plasma, proving its effectiveness in the treatment of facial aesthetic changes such as wrinkles, sagging, accentuated expression lines, acne, scars from acne, in addition to a significant improvement in skin hydration and reduction of enlarged pores.

Aplicación móvil para diagnóstico, prevención y tratamiento estético del acné II / A Mobile Application for Diagnosis, Prevention and Cosmetic Treatments of Grade II Acne

Introducción: Algunos profesionales tienen dificultades para hacer la detección correcta de los signos y síntomas y para prescribir el tratamiento adecuado del acné II, que puede conducir a un tratamiento estético insatisfactorio. Por lo tanto, es necesario desarrollar tecnología educativa, por ejemplo, una aplicación. Objetivo: Desarrollar una aplicación multimedia en una plataforma móvil para el diagnóstico, prevención y tratamiento estético del acné grado II. Métodos: Las fases de desarrollo de la estructura de la aplicación fueron: Fase 1 - "Concepción: identificación de las necesidades del desarrollo de la aplicación". Fase 2 - "Elaboración del prototipo de aplicación": esta fase incluyó la revisión integradora de la literatura en las principales bases de datos. Fase 3- "Creación de la aplicación": esta fase consistió en desarrollar el algoritmo, estructurar la base de datos y desarrollar el software; Fase 4- "Transición": se realizaron las pruebas de funcionalidad de la aplicación. Resultados: La aplicación móvil consta de 10 pantallas descriptivas y 4 pantallas con videos explicativos, el cual se registró en el Instituto Nacional de Propiedad Industrial (Ministerio de Desarrollo, Industria y Comercio Exterior) con el número de protocolo: BR: 51 2018 0001475 y está disponible de forma gratuita en línea en Google Play Store con el nombre de Face Care. Conclusión: El estudio permitió describir las etapas de planificación y desarrollo de una aplicación multimedia en una plataforma móvil para el diagnóstico, prevención y tratamiento estético del acné grado II(AU)

Introduction: Some professionals have difficulties in correctly detecting signs and symptoms of acne II, as well as in prescribing the appropriate treatment for the condition, a fact that can lead to unsatisfactory cosmetic treatment. Therefore, it is necessary to develop educational technology; for example, an application. Objective: To develop a multimedia application on a mobile platform for diagnosis, prevention and cosmetic treatment of grade II acne. Methods: The application structure was developed in four phases: conception (identification of the application development needs), development of the application prototype (which included the integrative review of the literature from the main databases), creation of the application (which consisted in developing the algorithm, structuring the database and developing the software), and transition (during which the application's functionality tests were carried out). Results: The mobile application consists of ten descriptive screens and four screens with explanatory videos. It was registered within the National Institute of Industrial Property (Ministry of Development, Industry and Foreign Trade), with the protocol number BR: 51 2018 0001475. It is available online, for free, on the Google Play Store, under the name Face Care. Conclusion: This study allowed to describe the planning and development stages of a multimedia application on a mobile platform for the diagnosis, prevention and cosmetic treatment of grade II acne(AU)

Avaliação da qualidade de vida e perfil epidemiológico de mulheres adultas com acne facial / Evaluation of quality of life and epidemiological profile of adult women with facial acne

Introdução: A acne é uma doença inflamatória crônica da unidade sebácea. Embora acometa principalmente adolescentes, constata-se uma prevalência elevada em adultos, em especial nas mulheres. A acne feminina adulta tem sido associada a má qualidade de vida (QV) e é capaz de impactar tanto a autoestima como os relacionamentos pessoais e profissionais. Métodos: Trata-se de um estudo transversal de natureza quantitativa realizado através da aplicação de questionários para avaliar a QV e o perfil epidemiológico de mulheres adultas com acne facial entre 25 e 50 anos atendidas em um ambulatório clínico da Universidade do Extremo Sul Catarinense (UNESC). Resultados: Um total de 20 mulheres com acne facial participaram da pesquisa. A idade média foi de 32,45 anos, sendo a maioria branca, casada e com ensino superior incompleto. A maioria não realizou tratamento prévio, e o perfil mais encontrado foi de início da acne na adolescência e de sua persistência na idade adulta. Grande parte das mulheres utilizavam maquiagem. Além disso, foram observados baixos escores em cada um dos quatro domínios do questionário Acne-QoL, com resultados estatisticamente significativos correlacionando a idade com os domínios de autopercepção e de papel emocional. Conclusões: Os resultados destacam que a acne facial tem um impacto significativo na QV de mulheres adultas que a possuem. (AU)

Introduction: Acne is a chronic inflammatory disease of the sebaceous unit. Although adolescents are most commonly affected, there is a high prevalence in adults, especially in women. Acne in adult women has been linked to poor quality of life and may affect self-esteem and personal and professional relationships. Methods: This quantitative cross-sectional study consisted of the administration of a questionnaire to assess the quality of life and epidemiological profile of adult women with facial acne aged 25 to 50 years who were treated at an outpatient clinic at University of Southern Santa Catarina (UNESC). Results: In total, 20 women with facial acne participated in this study. Mean age was 32.45 years, and most participants were white, married, and did not complete their higher education studies. Most of them did not undergo a previous treatment, and the most common profile was acne onset in adolescence with persistence in adulthood. Most women reported using makeup. In addition, low scores were found in all four domains of the Acne-Quality of Life questionnaire, with statistically significant results correlating age with the domains of self-perception and emotional role. (AU)

A randomized, comparative study on the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide 5% gel in the treatment of mild to moderate acne vulgaris

Introduction@#Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess se- bum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xantho- nes, which has high antimicrobial activity against C. acnes.@*Objectives@#To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treat- ment of mild to moderate acne vulgaris.@*Methods@#A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA) for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an 8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or 1) based on the IGA and any adverse reaction.

Analysis on formulation regularity and characteristics of acne-relieving Chinese medicinal health products and Chinese patent medicines / 中国中药杂志

This study summarized and analyzed the current acne-relieving Chinese medicinal health products and Chinese patent medicines,aiming at providing references for the formulation and development of acne-relieving health products. The information on acne-relieving health products published by the Department of Special Food Safety Supervision and Management,the State Administration for Market Regulation( SAMR) was retrieved,and the Chinese patent medicines on DRUGDATAEXPY were searched. Microsoft Excel and the Traditional Chinese Medicine Inheritance Support System V2. 5( TCMISS) were employed to statistically analyze the characteristics of formulations. Forty-three acne-relieving health products were obtained,including 40 ones containing Chinese herbal medicines. Six Chinese herbal medicines showed a usage frequency ≥8,with 61 times in use totally,including Salviae Miltiorrhizae Radix et Rhizoma( 13),Lonicerae Japonicae Flos( 12),Taraxaci Herba( 11),ALOE( 9),Carthami Flos( 8),and Rhei Radix et Rhizoma( 8). A total of 29 Chinese patent medicines with similar efficacy were collected in DRUGDATAEXPY. Nine Chinese herbal medicines showed a usage frequency ≥6,with 63 times in use,including Rhei Radix et Rhizoma( 10),Glycyrrhizae Radix et Rhizoma( 8),Scutellariae Radix( 8),Lonicerae Japonicae Flos( 7),Angelicae Sinensis Radix( 6),Paeoniae Radix Rubra( 6),Astragali Radix( 6),Paeoniae Radix Alba( 6),and Gardeniae Fructus( 6). Through unsupervised hierarchical entropy-based clustering of the above-mentioned Chinese medicinal health products and Chinese patent medicines,five and three new formulas were obtained,respectively. The selection of Chinese herbal medicines was consistent with the principles of traditional Chinese medicine( TCM) theories in relieving acne,i. e.,dispelling exterior wind,ventilating lungs,clearing heat,dissipating mass,promoting diuresis,relaxing bowels,removing toxin,activating blood,resolving stasis,eliminating phlegm,and regulating Qi. According to the " lung governing skin and body hair" and " interior-exterior relationship between lung and large intestine" in TCM theories,the idea that acne could be treated by relieving constipation was proposed,which provided new methods and references for the research and development of Chinese medicinal health products.